HORDB

ID: hor001151
Uniprot ID: H2D5R9
Protein name: Neuropeptide AF29
Gene name: afp-11
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: NAEPNFLRF
Length: 9(121-129)
Propeptide: MSPLHVALFLIFCSSQVLGECCNDGQTSDFCAVFNMLSPTEQAEVRSYLGDNCDGDADEAVRKIEKRKPNFIRFGRTAPPLTFGKKGSDPNFLRFGRTPSNNFLRFGKSNQAQNFLRFGRNAEPNFLRFGRPADPNFLRFGKSAEPNFLRFGKRSDIGISEPNFLRFGRNNFLRFGRNDQFDREYRKPNFLRFGK
Signal peptide: MSPLHVALFLIFCSSQVLG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001151_AF2.pdb

hor001151_ESM.pdb

Mass:	125010	Formula:	C51H74N14O14
Absent amino acids:	CDGHIKMQSTVWY	Common amino acids:	FN
pI:	6.41	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	-60	Boman Index:	-2232
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.44
Instability Index:	3498.89	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 21524146
Title: Discovery of Neuropeptides in the Nematode Ascaris Suum by Database Mining and Tandem Mass Spectrometry